Well, that depends on what counts as "hard".
From one point of view,
it's really easy to damage them electrically - just connect straight
to
mains power; few RS232 ports will withstand that, even over here
where
mains pwoer is only half the voltage it is on your side of the pond.
But it _is_ true that it's hard for someone not totally boneheaded to
damage them accidentally.
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If you are hell-bent on killing something, mains power applied between
appropriate terminals will usually do the job, even for otherwise robust
devices such as 2N3055s or big speakers. Unless of course it's a washing
machine, in which case a hand grenade or dynamite would be more useful.
Or 10kV from the local substation.
/Jonas