Adobe Acrobat has almost unlimited manipulation capabilities. You can
rearrange pages, add pages (from almost any format .... word documents,
JPEGs, other PDFs, scanners, TIFF .... just about anything), rotate pages,
delete pages, and export pages as graphic images (in just about any format).
You can export pages, do "whatever" to them, and reimport them.
Also, it may be possible to "re-image" the entire PDF file to shrink it's
size, although I've not done that. If you drop any requirement for
compatibility with versions of Acrobat versions 4 and earlier (the current
version is 7), the files can be shrunk dramatically, although I'm not sure
if there is an easy one-step way to do this in the "standard" version (there
is a separate stand-alone PDF file optimizer in the "pro" version). In my
own view, Acrobat versions 4 and earlier are now too old to be productively
used.
Of course, I'm talking about "full version" Adobe Acrobat, not simply the
[free] "Acrobat Reader".