There are probably cases of certain OSes refusing to
run because the
host platform has _too much_ RAM, but I'm struggling to think of any
right now.
Some of NetBSD's ports have had such issues, either because too much
RAM means more page tables than various parts of the system are
prepared to deal with or because of addressing issues (eg, a pre-PAE
i386 kernel may well have trouble with more than 4G of RAM). Not
often, but it has happened.
There are other issues - such as the time required to take a kernel
coredump - but they aren't "refusing to run".
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