They can get gassy. If the getters aren't nice
and shiny the tube is gone; if the are it still makes sense (especially on things that run
with significant B+) to bring them up on heater only and let them bake for a while.
There is very little you can do to prevent a tube going gassy, other
than keeping it out of a corrosive environment, where corrosion on a
pin can break the glass-metal seal. When a tube wants to go, it is
generally going to go.
--
Will