(Interesting
question, though - I wonder what a CPU might look like where
you
could just throw C source code at it, for instance :)
Well, there *was* the
AT&T Hobbit:
http://en.wikipedia.org/wiki/AT%26T_Hobbit
Not quite that, but still optimized for C, allegedly. Never worked with
the architecture myself.
AVR microcontrollers are said optimized for C, but there is an excellent
assembler, the AVR Studio.