I was able to do an entire fiche sheet in about 10 minutes with an Epson
Perfection (with transparency backlight) and their software.
The way to do it is to set up a spot on the scanner bed where you will
spot each sheet. After doing a reference scan, the software allows you
to make up a scan area select icon, which I placed around one of the
images on the reference scan. I can also see the size to be able to
recreate the shape each time i restart.
You can place it over each image, and the scanner will do the scan for
each image as you hit the scan button. I would then manually move the
icon to the next image on the sheet, till done.
I set the resolution high enough on the scans to produce an image
equivalent to what one would get if scanning an 8 1/2 x 11 page (what
the images were) if scanning at 400dpi.
The main project is the War Diaries of a US Navy Squadron, but you can
see the results here:
http://vpb208.org/Diaries%20and%20Documents.html
Jim